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Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract: However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classificationGreat efforts have been made to incorporate new information about the molecular landscape of gliomas

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

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Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 147-149 doi: 10.1007/s11684-013-0274-2

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, butas “genetic interpreters” or “genetic translators” and build a link between molecularSubsequently, by using their findings, oncologists will carry out targeted therapy based on molecularclassification.

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract: Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generationsequencing, have recently been developed to facilitate effectively its molecular classification.The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecularclassification scheme may promote individualized treatment and improve clinical outcomes.This review focuses on the molecular classification of NSCLC based on gene expression microarray technology

Keywords： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classificationdifferent tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecularThe dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract: Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improveIn this review, we summarize the findings in investigating the molecular alterations and clinical relevance

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 122-133 doi: 10.1007/s11684-012-0193-7

Abstract: In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs forTo date, the molecular classification of HCCs has been carried out through transcriptomic, genetic andSuch research has led to identification of several potential molecular targets in HCC, and subsequentlyIn this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potentialimmunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular

Keywords： hepatocellular carcinoma     molecular classification     molecular targeted therapies     tumor microenvironment    

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysisclassification method is confirmed by Japan Highway Public Corporation that this method can figure outThese equations as a new method were able to optimize the support system for and classification systemsFrom classification and its application in these case studies, it is pointed out that the methodfor the design of support systems in underground working is more reliable than the and classification

Keywords： JH classification     Q and RMR classification     new method    

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An approach for mechanical fault classification based on generalized discriminant analysis

LI Wei-hua, SHI Tie-lin, YANG Shu-zi

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 3,   Pages 292-298 doi: 10.1007/s11465-006-0022-2

Abstract: To deal with pattern classification of complicated mechanical faults, an approach to multi-faults classificationKPCA is good at detection of machine abnormality while GDA performs well in multi-faults classificationWhen the proposed method is applied to air compressor condition classification and gear fault classification, an excellent performance in complicated multi-faults classification is presented.

Keywords： generalized discriminant     non-separable     abnormality     classification     multi-faults classification    

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EAI-oriented information classification code system in manufacturing enterprises

WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 81-85 doi: 10.1007/s11465-008-0011-8

Abstract: Although the traditional information classification coding system in manufacturing enterprises (MEs)integration (EAI) in manufacturing enterprises, an enterprise application integration oriented information classificationEAIO-ICCS expands the connotation of the information classification code system and assures the identity

Keywords： EAI     EAIO-ICCS     management     classification     connotation    

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Fault classification and reconfiguration of distribution systems using equivalent capacity margin method

K. Sathish KUMAR, T. JAYABARATHI

Frontiers in Energy 2012, Volume 6, Issue 4,   Pages 394-402 doi: 10.1007/s11708-012-0211-0

Abstract: This paper investigates the capability of support vector machines (SVM) for prediction of fault classificationHere, the SVM has been used as a classification.

Keywords： machines (SVM)     structural risk minimization (SRM)     equivalent capacity margin (ECM)     restoration     fault classification    

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Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 1-3 doi: 10.1007/s11705-021-2134-y

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Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 168-182 doi: 10.1007/s11705-021-2056-8

Abstract: In this work, computer-aided molecular design tools were developed to design optimal solvents to upgradeAs different property prediction models consist different levels of structural information, molecularDue to the combinatorial nature of higher-order signatures, the complexity of a computer-aided molecular

Keywords： computer-aided molecular design     bio-oil additives     molecular signature descriptor    

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Multiclass classification based on a deep convolutional

Ying CAI,Meng-long YANG,Jun LI

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 11,   Pages 930-939 doi: 10.1631/FITEE.1500125

Abstract: Finally, feature extraction filters are optimized together with the weight of the classification componentthrough training, to minimize the classification error.

Keywords： Head pose estimation     Deep convolutional neural network     Multiclass classification    

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Modular design of typical rigid links in parallel kinematic machines: Classification and topology optimization

Xinjun LIU, Xiang CHEN, Zhidong LI

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 2,   Pages 199-209 doi: 10.1007/s11465-012-0315-6

Abstract: seeking optimal structures with best mechanical performances is analyzed and processed in two steps: classification

Keywords： parallel kinematic machines (PKMs)     modular design     classification     topology optimization and improved Guide-Weight    

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Title Author Date Type Operation

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article

Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

An approach for mechanical fault classification based on generalized discriminant analysis

LI Wei-hua, SHI Tie-lin, YANG Shu-zi

Journal Article

EAI-oriented information classification code system in manufacturing enterprises

WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing

Journal Article

Fault classification and reconfiguration of distribution systems using equivalent capacity margin method

K. Sathish KUMAR, T. JAYABARATHI

Journal Article

Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Journal Article

Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Journal Article

Multiclass classification based on a deep convolutional

Ying CAI,Meng-long YANG,Jun LI

Journal Article

Modular design of typical rigid links in parallel kinematic machines: Classification and topology optimization

Xinjun LIU, Xiang CHEN, Zhidong LI

Journal Article